The wide variety of problems presented by smart pumps can have adverse impacts on an organization’s staff time, costs, and most important, patient safety. There are numerous challenges with drug libraries, such as bypassing drug libraries, balancing limits and alert fatigue, cumbersome drug library development, long and inefficient update process, underutilization of data, and missed quality improvement opportunities. Fortunately, where there are challenges, there are possibilities to implement solutions that can help to improve efficiency and safety.